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KMID : 0391419930030010059
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Korean Journal of Lipidology
1993 Volume.3 No. 1 p.59 ~ p.67
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Serum Lp(a) Concentrations in Diabetic Nephropathy & Nephrotic Syndrome
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유순집
권혁호/윤건호/우제영/차봉연/이광우/손호영/강성구
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Abstract
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There are intimate relationship between dyslipidemia and atherosclerosis. The incidence and the mortality of cardiovascular disease increased in proteinuric disorder such as diabetic nephropathy and nephrotic syndrome. Recently there were
evidence
that
increased concentrations of serum Lp(a), which is independent risk factor to atherosclerotic cardiovascular and cerebrovascular disease, in proteinuric disorder.
We intended to search and identify the mechanism of altered concentrastions of Lp(a) in proteinuric disorder via measuring serum Lp(a) concenrtrations with ELIZA in 26 patients with diabetic nephropathy, 20 patients with nephrotic syndrome and 54
control.
@ES The results were as follows
@EN 1) There were significantly increased amounts of 24 hour urine protein in diabetic nephropathy group[DN] (6.0±4.5g/dl) and nonremission group [R-] (4.8±1.8g/dl) of nephrotic syndrome compared to remission group[R+] (0.7±0.4g/dl) (p<0.05)
and
significantly decreased serum albumin level in [R-](2.2±1.3g/dl) compared to [DN](3.1±0.6g/dl) and [R+](3.4±0.8g/dl) (p<0.05) and significantly decreased serum protein level in [R-](6.6±0.7g/dl) compared to [R+](5.1±1.2g/dl)(p<0.05).
2) There were significantly increased level of total cholesterol and LDL-cholesterol in [R-](327.8±141.3g/dl & 234.1±129.7mg/dl) compared to [DN](246.6±66.4/dl)(p<0.05), but no signisicant difference in triglyceride and HDL-cholesterol among
[R-],
[R+] and [DN] (P>0.05).
3) There were significantly increased concentration of serum Lp(a) in [DN] [median36.3(range 4.0-164.0mg/dl)], [R+][28.3(15.0-145.0mg/dl)], [R-][130.5(10.1-177.0mg/dl)] compared to control [median 13.0 (range 1.0-70.0mg/dl)](p<0.05). And there
were
significant difference in serum Lp(a) concentration of [R-] compared to [DN] and [R+](p<0.05).
4) There were significant correlations in serum Lp(a) concentrations with serum albumin, total cholesterol and LDL-cholesterol, but no significant correlations in age, sex, fasting blood sugar, serum creatinine, triglyceride, HDL-cholesterol and
24hr
urine protein in proteinuric disorder.
There were statistically significant increased concentrations of serum Lp(a) in proteinuric disorder compared to control group and the concentrations were variable according to kind and state of disease. The results suggested that increased
hepatic
synthesis of Lp(a) would be one of the mechanism of increased concentrations of serum Lp(a) in these proteinuric disorder and it would be relate to decrease level of serum albumin.
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KEYWORD
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